Medicinal Chemistry Research Group (UAMC)

The major research lines in the Medicinal Chemistry group all deal with design, synthesis and characterisation of biologically active, small organic molecules and applying these molecules in models of human pathology. While dedication in this area is highly focused on enzymological targets and includes both reversible and irreversible modifiers of enzymatic activity, our group has over the years gathered singular expertise with covalent and irreversible types of enzyme inhibitors. Compounds with such a mechanism of action are not only investigated for their powerful inhibitory effect per se, but also for their potential to serve as probe molecules in chemical biology and biomarker research. The different research themes in the Medicinal Chemistry group can found in project and publications.