Electrochemical aptasensing

Aptamers, synthetic oligonucleotides also known as “artificial antibodies”, offer great potential as bio-recognition element in biosensors. DNA or RNA aptamers are considered as a new generation of synthetic biorecognition elements which challenges antibodies and enzymes in many aspects.

Today the demand for sensitive and selective detection systems resounds from the health, food and environmental sector. These systems must be able to detect and quantify target molecules, important for assessing the level of contamination in food & feed and environmental samples. Electrochemical sensors are very attractive for monitoring the presence of pollutants as these devices are fast, portable, extremely sensitive and selective towards redox species, especially when a bio-recognition element is integrated onto the electrode surface. Electrochemical biosensors are analytical devices that consist of a sensitive biological recognition material targeting an analyte of interest and a transduction element for converting the recognition process into an amperometric, potentiometric or impedimetric signal. 

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Key Publications:

  • 'Label-Free Impedance Aptasensor for Major Peanut Allergen Ara h 1', Stanislav Trashin et al., Electroanalysis, 2015, 27(1), 32–37.
  • 'Carbon nanotubes based electrochemical aptasensing platform for the detection of hydroxylated polychlorinated biphenyl in human blood serum', Sanaz Pilehvar et al., Biosens. Bioelectron., 2014, 54, 78–84.
  • 'Aptasensing of Chloramphenicol in the Presence of Its Analogues: Reaching the Maximum Residue Limit', Sanaz Pilehvar et al., Anal. Chem., 2012, 84(15), 6753–6758.