Singlet oxygen-based electrosensing and photoelectrochemical sensors

Enzyme-based electrochemical biosensors are an inspiration for the development of (bio)analytical techniques. However, the instability and reproducibility of the reactivity of enzymes, combined with the need for chemical reagents for sensing remain challenges for the construction of useful devices. We introduced a sensing strategy inspired by the advantages of enzymes and photoelectrochemical sensing, namely the integration of aerobic photocatalysis and electrochemical analysis. The photosensitizer, a bioinspired perfluorinated Zn phthalocyanine, generates singlet-oxygen from air under visible light illumination and oxidizes analytes, yielding electrochemically-detectable products while resisting the oxidizing species it produces. Compared with enzymatic detection methods, the proposed strategy uses air instead of internally added reactive reagents, features intrinsic baseline correction via on/off light switching and shows C-F bonds-type enhanced stability. It also affords selectivity imparted by the catalytic process and high sensitivity that results in  detection of amoxicillin in the nanomolar range.

 

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Key publications:

  • 'Optimized Photoelectrochemical Detection of Essential Drugs bearing Phenolic Groups.', Liselotte Neven et al., Analytical Chemistry, 2019, 91(15), 9962-9969
  • 'Photodegradation mechanisms and kinetics of Eosin-Y in oxic and anoxic conditions.', Alba Alvarez-Martin et al., Dyes and Pigments, 2017, 145, 376-384.
  • 'Singlet oxygen-based electrosensing by molecular photosensitizers', Stanislav Trashin et al., Nat Commun. - ISSN 2041-1723-8 (2017) .