animal models

Nephrotoxic animal models:

  • cyclosporine rat model
  • cisplatine rat model

Gastric pathology animal models:

  • Helicobacter pylori mouse model for gastric pathology  (mouse C57BL/6)
  • Muc13-/- knock out (mouse C57BL/6 background)

Gastroenterology: animal models:

  • gastrointestinal inflammation: TNBS and DSS colitis (rat; mouse)
  • T cell transfer model for chronic colitis (mouse)
  • sepsis: postoperatieve ileus and septic ileus (cecal ligation and puncture; LPS) (mouse)

Hepatology: animal models:

  • portal hypertension: common bile duct ligation (rat)
  • NAFLD/NASH: MCD diet, HFD ( +/- fructose ) (rat, mouse)
  • Hepatocellular physiology: Hepatocellular autophagy-deficient mice