The application fields in which the Centre for Proteomics instrumentation is used, span a very wide range of research topics. Typically, every core research group has its own research interest.
In short, these research fields can be described as:
Clinical Proteomics (VITO-UAntwerp)
- Immunopeptidomics
- Peptide-centric proteomics for identification and PTM characterization
- Quantitative proteomics by label-free or labelled analysis workflows
- Peptidomics: characterization and quantification
- Targetted measurements of proteins and peptides via SRM, PRM
- Protein co-purification technology, e.g., ASBA membrane protein enrichement, etc.
- Isolation of extra-cellular vesicles and exosomes
- Analytical and technological proteomics expertise
- Translational research – from bench to bedside
- Data-mining and bio-informatics for proteomics and mass spectrometry
- Development of software suites for customized analysis
- Imaging mass spectrometry
Proteinchemistry, proteomics and epigenetic signalling – PPES (UAntwerp)
- Differential (chemo)proteomics for cancer research
- PTM analysis and biomarker identification.
- MRM quantification of cancer biomarker proteins
- OBOC hexapeptide identification
- Differential proteomics in biofilm formation and evaluation of treatment
- Native MS and ion mobility approaches for structural biology of heme-proteins
- Study of membrane proteins using native MS
- Effect of oxidative stress on heme-proteins
Systemic Physiological & Ecotoxicological Research - SPHERE (UAntwerp)
- In search for mechanistic insights (mode-of-action) of (environmental) toxicants
- Identification of molecular classifiers and their relation to toxicity at higher levels of organization
- Mechanistic insights of mixed stress scenarios (exposures to multiple compounds)
- Effects of confounding factors (like temperature deviations)
- Toxicity of environmentally persistend pharmaceutical pollutants
- Differential peptidomics: in search for effects on endogenously occurring peptides
- Differential proteomics
Biomolecular & Analytical Mass Spectrometry – BAMS (UAntwerp)
- Development of novel separation, identification and fragmentation techniques for proteomics, peptidomics and metabolomics.
- MS imaging of biomolecules (SIMS)
- Native MS and ion mobility approaches for structural biology.
- Chemical crosslinking, HDX and covalent labelling.
- Biopharmaceuticals characterization. Ligand binding studies.
- Molecular modelling and gas-phase characterization (spectroscopy).
- (Isomer) separation and characterization of drug-like molecules using ion mobility MS. Native MS and ion mobility approaches for structural biology.
Translational neurobiology (VIB-UAntwerp)
- Quantitative spatiotemporal proteomics of neurodegenerative diseases
- iTRAQ/TMT and SILAC-based proteomic analysis
- Proteomics-based molecular disease signature analysis
- Receptor-based phosphoproteomic signal transduction profiling
- Intelligent plasma proteome investigation
- Bioinformatic software application development
- Differential and quantitative interactomics
- Multo-tissue based proteomic investigation of pathological aging
More info about the different research topics can be found on the webpages of the respective CORE research groups.