Research team

Expertise

Contract syntheses.

Study of a new halide effect in palladium catalyzed C-C bond forming reactions and development of new antiplatelet agents based on a pyridazin-3(2H)-one skelet. 01/10/2006 - 30/09/2008

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of New Platelet Aggregation Inhibitors based on a Pyridazin-3(2H)-one core. 01/01/2006 - 30/06/2006

Abstract

The effect of substitution on the C-4 position of 2-methyl-5-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-one on the platelet aggregation inhibition will be investigated. In addition the influence of moving the 3-oxo-3-phenylprop-1-en-1-yl group on C-5 to C-4 and C-6, as well as substitution of this group for a (phenylsulfinyl)vinyl-, a (phenylsulfonyl)vinyl- and a (diphenylphosphoryl)vinyl group will be studied.

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Nucleophilic Substitution of Hydrogen under Temperature-Controlled Microwave Heating. 01/04/2005 - 31/12/2005

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In this project alternative reagents for SNH amination reactions such as the Chichibabin reaction and the oxidative amino-dehydrogenation will be investigated. The effect of fast and homogeneous heating by microwave radiation on s-adduct formation and rearomatization will be investigated. The new reaction conditions have to avoid the drawbacks of the cited reactions and combine the advantages.

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Pyridazine Derivates : Investigation of new methods for the direct introduction of carbon substituents and study of a new halide effect in palladium catalyzed C-C bond forming reactions. 01/10/2004 - 30/09/2006

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In this project a new effect of halide anions on transition metal catalysed reactions will be investigated. In addition, new methods for the C-functionalisation of the pyridazine nucleus will be studied via metal-halogen exchange.

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Development of new antiparasitic lead compounds against malaria, trypanosomiasis en leishmaniasis : a multidisciplinary approach. 01/01/2004 - 31/12/2007

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Parasitic infections such as malaria, trypanosomiasis and leishmaniasis still make a lot of victims every year, especially in developing countries. The aim of this project is to investigate new lead compounds for drugs against these diseases using a multidisciplinary approach: characterisation of new leads from medicinal plants; further investigations of indoloquinoline derivatives, an existing lead; and design of inhibitors of trypanothionsynthetase and prolyloligopeptidase.

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01/07/2003 - 31/12/2003

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01/07/2003 - 31/12/2003

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01/12/2002 - 31/12/2002

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    01/12/2002 - 31/12/2002

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      01/09/2002 - 28/02/2003

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        01/05/2002 - 30/04/2004

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        Submitting novel chemical compounds in accordance with the research strategy defined by the team. 01/11/2001 - 31/10/2003

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        01/10/2001 - 31/01/2003

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          Palladium-catalyzed syntheses of pyridazine derivates 01/01/2001 - 31/12/2001

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          A fundamental study on the influence of the type of the halogens on the transmetallationstep in the catalytic cycle of palladium-catalyzed syntheses of pyridazine derivates wille be executed.

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            01/07/2000 - 31/12/2000

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              Solid phase synthesis of pyridazinamines and pyridazinones by cross coupling reacties. 01/01/2000 - 30/11/2000

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              A pyridazine synthon will be coupled to a polystyreen resin and derivatized by suzuki or Stille Reactions on the pyridazine ring. This strategy will allow us to synthesize known biologically active pyridazine derivates in a more efficient way and to prepare new types which could not yet be synthesized.

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                01/10/1997 - 30/09/1998

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                  01/01/1997 - 31/12/1997

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                    01/10/1993 - 30/09/1994

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