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Introduction
Metabolomics is the study of small molecules (< 1400 Da) in the organism. Since it is most downstream of the cellular organisation, the metabolome is closest to the actual phenotype of the human, giving it a more accurate reflection of the health condition of the subjects monitored.
The use of Ultra Performant Liquid Chromatography in combination with High Resolution Mass Spectrometry provides a platform for untargeted metabolomics studies, generating big data. In combination with multi-variate statistics, these fingerprints are related to toxicological responses. As a result, new mechanisms of toxicity can be discovered, providing biomarkers for further research.