Research team
Gene expression analysis of human inflammatory breast cancer.
Abstract
Researcher(s)
- Promoter: Van Marck Eric
- Co-promoter: Vermeulen Peter
- Fellow: Van der Auwera Ilse
Research team(s)
Project type(s)
- Research Project
Gene expression micro-array analysis of early stage breast cancer : confrontation with morphological markers of hypoxia and (lymph)angiogenesis and with molecular detection of minimal disease in blood, bone marrow and lymph nodes.
Abstract
Researcher(s)
- Promoter: Van Marck Eric
- Co-promoter: Vermeulen Peter
Research team(s)
Project type(s)
- Research Project
Study of the prevalence and prognostic/predictive value of heterogeneous vascular/angiogenic dependence in human primary breast cancer and in metastases of adenocarcinomas of the breast and the colon.
Research of the mechanisms responsible for (i) chronic allograft nephropathy (ii) interaction between tumour cells and stromal cells (iii) partial protection of chronic renal failure against acute ischemia.
Abstract
Researcher(s)
- Promoter: De Broe Marc
- Co-promoter: Bosmans Jean-Louis
- Co-promoter: Van Marck Eric
- Co-promoter: Van Rompay An
- Co-promoter: Vermeulen Peter
Research team(s)
Project type(s)
- Research Project
Effect of host factors on the genesis and behaviour of malignant tumours. Development of new therapeutic strategies.
Abstract
The aim of our project is to develop new strategies for cancer treatment in which host cells serve as a target. Host cells are in most tumours genetically unaltered. The part of the project which will be performed at the UA will be focused on the interaction between coagulation end angiogenesis. Host cells are genetically unaltered, and thus more stable. They influence tumour growth by paracrine and endocrine intcractions. Angiogenes is based on proliferation and migration of genetically unaltered endothelial cells, supplied by the host. Bloodvessel density in tumours and serum concentrations of angiogenic factor such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor, both reflecting the intensity of ongoing angiogenesis, are associated with the incidence of metastasis end with tumour growth kinetica in cancer patients. Our team will investigate the interaction between blood coagulation pathways and angiogenesis. Cancer patients often have elevated platelet counts and high concentrations of circulating cleavage products of fibrin. The role of thrombocytes, and the thrombopoietic end indirectly angiogenic cytokine interleukin-6, in the endocrine action of angiogenic factors, e.g. VEGF, and the role of extravascular coagulation for tumour growth, will be adressed. The effect of inhibitors of thrombocyte degranulation on tumour progression will be analysed.Researcher(s)
- Promoter: Vermeulen Peter
Research team(s)
Project type(s)
- Research Project