Bart Cuypers

Doctoraatsstudent - Aspirant FWO

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Bart graduated as a Master in Biology: Cell & Systems Biology at the University of Antwerp in 2013. Currently he is a last year PhD Student in Systems Biology, Bio-informatics and Data Mining, holding an ‘Aspirant’ Fellowship of the FWO. He works in two research groups and combines the techniques of both. At one side he is member of the ADReM group (Advanced Database Research and Modelling) and working under supervision of Prof. dr. Kris Laukens. Their research focusses on bio-informatics, data-mining and network biology with a vast variety of applications. Secondly, he is part of the Molecular Parasitology Unit (MPU) lead by Prof. dr Jean-Claude Dujardin, located in the Institute of Tropical Medicine, Antwerp.

Specifically, Bart studies the parasite Leishmania donovani, which is responsible for the disease visceral leishmaniasis. Each year, over 5 million people contract this disease, which is lethal without treatment. His research focusses on unraveling developmental and drug-resistance mechanisms of the parasite by collecting (wet-lab, MPU) and integrating genomics, transcriptomics, proteomics and metabolomics data (ADReM).

Recente Publicaties

Cuypers, B., Van den Broeck, F,   Van Reet, N., Meehan, CJ., Cauchard, J., Wilkes, JM., Claes, F., Goddeeris, B.,  Birhanu H., Dujardin JC, Laukens, K., Büscher, P., Deborggraeve, S. Genome-wide SNP analysis reveals distinct origins of **Trypanosoma evansi** and **Trypanosoma equiperdum** Genome Biology and Evolution - ISSN 1759-6653-9:8 (2017) p. 1990-1997.Modulation of aneuploidy in **Leishmania donovani** during adaptation to different in vitro and in vivo environments and its impact on gene expression 

Dumetz, F., Imamura, H., Sanders M., Seblova, V., Myskova, J., Pescher, P., Vanaerschot, M., Meehan C.J., Cuypers, B., De Muylder, G., Späth, G.F., Bussotti, G., Vermeersch, J.R., Berriman, M., Cotton, J.A., Volf, P., Dujardin, JC, Domagalska M.
mBio - ISSN 2150-7511-8:3 (2017) p. 1-14

Cuypers, B., Domagalska, M.,  Meysman, P.,   De Muylder, G,  Vanaerschot, M., Imamura, H.,  Dumetz, F., Verdockt TW.,  Myler, PJ., Ramasamy, G.,  Laukens, K.,   Dujardin, JC. Multiplexed Spliced-Leader Sequencing : a high-throughput, selective method for RNA-seq in Trypanosomatids  Scientific reports - ISSN 2045-2322-7 (2017) 

Cuypers, B., Lecordier, L., Meehan, CJ., Van den Broeck, F., Imamura, H., Büscher, P., Dujardin, JC, Laukens, K, Schnaufer, A., Dewar, C., Lewis, M., Balmer, M., Azurago, T., Kyei-Faried, S., Ohene, S., Duah, B., Homiah, P., Kofi Mensah, E., Anleah, F., Franco,J.R., Pays,E., Deborggraeve, S. (2016). "Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection." mBio 7(2): e02198-02115.

Rai, K., Cuypers, B., Bhattarai, N. R., Uranw, S., Berg, M., Ostyn, B., … Vanaerschot, M. (2013). Relapse after Treatment with Miltefosine for Visceral Leishmaniasis Is Associated with Increased Infectivity of the Infecting Leishmania donovani Strain. mBio, 4(5), e00611–13.


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