Vascular dysfunction in chronic kidney disease: relevance and reversibility with exercise

Datum: 15 juni 2015

Locatie: UAntwerp - Campus Drie Eiken - Building Q - Promotiezaal - Universiteitsplein 1 - 2610 WILRIJK

Tijdstip: 16 uur

Organisatie / co-organisatie: Faculty of Medicine and Health Sciences

Promovendus: Amaryllis Van Craenenbroeck

Promotor: Prof M. Couttenye & Prof C. Vrints

Korte beschrijving: PhD defence Amaryllis Van Craenenbroeck - Faculty of Medicine and Health Sciences



Abstract

Cardiovascular disease is the main cause of morbidity and mortality in patients with CKD. As renal function declines, kidney‐specific risk factors come into play, and insight into these underlying mechanisms is mandatory to adequately tackle the cardiovascular burden in CKD. In this project we explored the possible role of impaired vascular repair mechanisms and circulating microRNA as novel risk factors.

Next, the reversibility of vascular dysfunction, characterized by endothelial dysfunction and arterial stiffness, was formally tested in a randomized controlled trial. Finally, the exploration of the acute exercise‐induced responses of both monocyte subsets and circulating microRNA, might contribute to a better insight into the cardiovascular adaptation to exercise in this vulnerable patient population.