Investigation of new approaches towards C8-N9 annulated purines
21 April 2016
Stadscampus, Promotiezaal van de Grauwzusters - Lange Sint-Annastraat 7 - 2000 Antwerpen
PhD defence Jens Maes - Department of Chemistry
Purine derivatives can interact with several biological receptors and therefore being used as a possible treatment of several diseases. The biggest challenge in obtaining good purine-based enzyme inhibitors and receptor (ant)agonists is to overcome the lack of selectivity for a specific enzyme/receptor. In this project the synthesis of novel (di)azino- and azolo annulated purines was envisioned to give access to a new group of possible biologically active compounds. An iron-catalyzed C-H amination reaction was successfully developed for the synthesis of (di)azino annulated purines. As an alternative a tandem C-X amination/aza-Wittig reaction was developed and probed for the synthesis of azolo annulated purines.