This course presents an introduction to and deals with the application and combination of physical methods in the determination of the structure of (in)organic molecules. The emphasis lies on the use of the spectroscopic techniques. This year-long course is divided into two parts.
In Part 1 (semester 1), after a general introduction on molecular structure, UV-vis spectroscopy, vibrational spectroscopy (IR and Raman), mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR) are discussed; in this first part NMR is limited to H-NMR. These techniques are combined in a number of integrated excercises.
In Part 2 (semester 2) NMR is extended to include the different types of C-NMR spectroscopy and these are likewise combined with the four techniques from Part 1 in an extended series of integrated exercises. Then the basic principles behind the different types of 2D-NMR techniques are discussed, i.e., COSY, HETCOR (HMQC and HMBC) and INADEQUATE. Likewise, the theoretical principles are amply illustrated via an extended series of integrated exercises. Solid-state NMR and the use of NMR spectroscopy on nuclei other than H and C is then briefly discussed. Finally, a short practical is organised in which the students, organized into small groups, will be allowed to experience the analysis of an unknown compound, going from sample preparation and recording the different kinds of spectra to their analysis.