The course starts with a discussion of the relations between structure and function and organism and environment. Within this framework special attention is given to the role of regulatory and adaptational mechanisms which has allowed different types of organisms to adjust and live in very different environments. De course continues with an exploration of basis organismal function starting with nerve, muscle and endocrine systems. Subsequently, the systems involved in homeostasis, movement and ion and osmoregulation are discussed. The circulatory system supplies the tissues of various substances and creates a constant internal environment. Feeding and digestion supplies the organism with the necessary energy and building blocks required to sustain homeostatic functions, growth and development. A final chapter focuses on the physiology of reproduction. The different topics are presented in a comparative manner using examples of mechanisms and processes from relatively simple unicellular organisms to highly developed and complex organisms such as mammals. Complimentary to the theoretical part a number of practical exercises are organised illustrating different aspects of functional morphology and physiology. Experiments include measurements of respiratory function, cardiovascular condition and ion and osmoregulatory functions.