Organic chemistry II

Course Code :1005WETCHE
Study domain:Chemistry
Academic year:2019-2020
Semester:1st semester
Sequentiality:Minimum 8/20 for Chemistry I & II and Organic chemistry I
Contact hours:59
Study load (hours):140
Contract restrictions: Exam contract not possible
Language of instruction:Dutch
Exam period:exam in the 1st semester
Lecturer(s)Bert Maes
Veerle Smout

3. Course contents *

This course deals with the most important organic reactions that the different classes of organic compounds can undergo or through which these compounds are formed. The IUPAC-nomenclature, which was already introduced in 'Organic Chemistry I' will be extended to other functional groups. The interconversion of functional groups will be approached from mechanistic point of view. Moreover the formation and reactivity of radicals will be discussed. Through the course the creative use of these reactions for the synthesis of new products and retrosynthetic thinking (disconnection) will be taught by means of examples and exercises. Because of the big importance of organic molecules in our society, various illustrations from pharmaceutical and agrochemical industry will be given. In close connection with this, within the framework of sustainable development, some examples of organic pollutants in our environment will be quoted.

The  practical course exists of four scientific experiments, in which different reaction mechanisms will be illustrated:
- synthesis of alkylacetates: fruit flavor (Fisher esterification);
- synthesis of cyclohexene (elimination);
- 1,3-diphenyl-2-propenon (aldol condensation);
- synthesis of azopigments: methyl orange (electrophilic aromatic substitution).
One week before the start of the first lab, the basic lab skills (reflux, distillation, extraction, melting point determination,...) will be introduced during a mandatory introduction course, along with a discussion of the safety regulations and the experiments that have to be performed in the lab.