Biocatalysis and Bioenergetics

Course Code :1008FBDBIC
Study domain:Biochemistry
Academic year:2017-2018
Semester:2nd semester
Contact hours:50
Study load (hours):196
Contract restrictions: Exam contract not possible
Language of instruction:Dutch
Exam period:exam in the 2nd semester
Lecturer(s)Sylvia Dewilde

3. Course contents *

The enzyme characteristics are discussed, as well as the effect of enzyme-, substrate-, inhibitor and activator concentration on kinetics. Mechanisms contributing to the raise of reaction speed by enzymes are studied using examples. Attention is given to the structure of the active center and substrate binding. De regulation of enzymatic activity by allostery, cooperativity and covalent modifications are as well studied.

Besides the basic elements of enzymology, an introduction in bio-energetics is given: how is the energy in a cell efficiently transported? An overview of oxidative breakdown of carbohydrates and light and dark reactions of photosynthesis is given.

The effect of hormones, growth factors, transcription factors and receptors (signal transduction cascades) on metabolism and on the discussed enzymes will be discussed.