Pharmacology and Applied Pharmacokinetics

Course Code :1027FBDFAR
Study domain:Pharmaceutical Sciences
Academic year:2017-2018
Semester:2nd semester
Sequentiality:
Contact hours:76.5
Credits:9
Study load (hours):252
Contract restrictions: Exam contract not possible
Language of instruction:Dutch
Exam period:exam in the 2nd semester
Lecturer(s)Guido De Meyer
Ingrid De Meester
Pieter-Jan Guns
Paul Fransen
Erik Mannaert

3. Course contents *

The first hours of the theory course are devoted to the introduction of two main aspects of General Pharmacology: Pharmacodynamics and Pharmacokinetics. Pharmacodynamics relate to the consequences of the interaction of a drug with its primary site of action. This part is largely devoted to principles of drug-receptor interactions. Different types of agonists and antagonists and the concepts of affinity and efficacy are presented.
Pharmacokinetics is the term describing the time course of drug concentrations in various parts of the body. Movement of drugs across cellular barriers, drug absorption (i.e. the transition from the site of application to the plasma), distribution of drugs in the body and elimination processes (metabolism and excretion) are dealt with. These basic principles are then applied to different compartment models to describe drug disposition in patients. Bioavailability, plasma clearance, the elimination constant and the half life of a drug and the effects of repeated dosage are presented.
The main part of the course is devoted to describe the mode of action, the effects and the major indications of several drug classes. The selection is restricted to drugs with applications in: the autonomic nervous system, allergy and inflammation, the cardiovascular system, thrombosis, analgesia (pain control), local and general anaesthesia, the airways, the gastrointestinal system, the central nervous system (neurodegenerative disorders, anxiolysis, psychosis, depression and epilepsy), the reproductive system and immunopharmacology.

 

The Applied Pharmacokinetics give the student practical examples of pharmacokinetics to achieve therapeutic or undesirable (toxic) drug effects in the patient using computer simulations. The student is asked to determine pharmacokinetic parameters of a drug (elimination half life, apparent volume of distribution) and to design an optimal dose regimen for a drug with a narrow therapeutic window, and to adapt this regimen according to patient-related factors, such as age, renal failure, or hepatic dysfunction. A brief report of the outcome of these simulations is requested.