Pharmacology

Course Code :1029FBDBMW
Study domain:Pharmaceutical Sciences
Academic year:2017-2018
Semester:2nd semester
Sequentiality:
Contact hours:40
Credits:5
Study load (hours):140
Contract restrictions: Exam contract not possible
Language of instruction:Dutch
Exam period:exam in the 2nd semester
Lecturer(s)Pieter-Jan Guns
Guido De Meyer

3. Course contents *

The first hours are devoted to introduce two main aspects of General Pharmacology: Pharmacodynamics and Pharmacokinetics.
Pharmacodynamics relate to the consequences of the interaction of a drug with its primary site of action. This part is largely devoted to principles of drug-receptor interactions. Different types of agonists and antagonists and the concepts of affinity and efficacy are presented.
Pharmacokinetics is the term describing the time course of drug concentrations in various parts of the body. Movement of drugs across cellular barriers, drug absorption (i.e. the transition from the site of application to the plasma), distribution of drugs in the body and elimination processes (metabolism and excretion) are dealt with. These basic principles are then applied to different compartment models to describe drug disposition in patients. Bioavailability, plasma clearance, the elimination constant and the half life of a drug and the effects of repeated dosage are presented.
The main part of the course (32 hours) is devoted to describe the mode of action, the effects and the major indications of several drug classes. The selection is restricted to drugs with applications in: the autonomic nervous system, allergy and inflammation, the cardiovascular system, thrombosis, analgesia (pain control), local and general anaesthesia, the airways, the gastrointestinal system and the central nervous system (neurodegenerative disorders, anxiolysis, psychosis, depression and epilepsy).