General pharmacology

Course Code :1035FBDDIE
Study domain:Pharmaceutical Sciences
Academic year:2017-2018
Semester:1st semester
Sequentiality:
Contact hours:32
Credits:3
Study load (hours):84
Contract restrictions: Exam contract not possible
Language of instruction:Dutch
Exam period:exam in the 1st semester
Lecturer(s)Erik Mannaert
Pieter-Jan Guns

3. Course contents *

The course starts with a general introduction to pharmacodynamics (4 hours). Principles of drug - receptor interactions, such as signal transduction, affinity, intrinsic activity, different types of antagonism, up- and down regulation, tachyphylaxis are discussed.

 

The remaining hours are devoted to pharmacokinetics. Absorption, distribution, metabolism and elimination of drugs (ADME), compartments, adaptation of doses and dose interval, elimination-t1/2 and bioavailability are discussed.

 

Physicochemical properties of the drug as well as physiological processes, which affect the pharmacokinetic profile of the compound, are illustrated. The physiological processes can change in relation to animal species, age, liver and kidney function. All those factors are important to determine the bioavailability of a drug. Changes in these parameters thus determine whether a compound will exert therapeutic or unwanted effects.