The course consists of a theoretical segment and a separate laboratory practicum. The theoretical segment is divided in four parts:
Part 1: Organic Synthesis
Part 2: Retrosynthetic Analysis
Part 3: Heterocyclic Chemistry
Part 4: Scope-Expanding Topics
In 'Organic Synthesis', knowledge of organic transformations is widened and deepened, furthering on the course of 'Organic Chemistry' (Bachelor 1). Signifcant attention goes to the development of mechanistic insight. There is a strong emphasis on reaction type and functional groups that are of interest to medicinal drugs and their synthetic preparation. The theoretical knowledge of this part will be further trained by means of exercices on multi-step synthesis of 'druglike' molecules.
In 'Retrosynthetic Analysis', the efficient design of multi-step synthetic routes is taught, starting from the retrosynthetic formalism. A clear link is again made with medicinal drugs and 'druglike' molecules. Exercices are offered to support development of the corresponding competence.
In 'Heterocyclic Chemistry', the nomenclature, reactivity and acid/base properties are discussed of the heterocyclic that occur most frequently in drugs. For each of these three subjects, specific exercices are foreseen.
The last part 'Scope Expanding Topics' offers the student an overview of actual topics and challenges in the synthesis of medicinal drugs and druglike molecules. Examples include 'green chemistry' and 'sustainable development', innovative chemical strategies for drug discovery, the implementation of Artificial Intelligence in the design and elaboration of multi-step synthetic schemes. This part of the course consists of recently published scientific articles (in English)
In the laboratory practicum, the student develops competencies in the field of practical Organic Synthesis, as used in the preparation of 'druglike' molecules. The practicum furthermore focuses on Chemical Safety and Good Laboratory Practices.