In this course, the student is given an insight in modern nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) and their applications in different fields of chemistry. Starting from the essential basic physical concepts of magnetic resonance (nuclear and electron spin, magnetization, Zeeman effect, radiofrequency and microwave pulses, relaxation effects) the basic concept of Fourier Transform NMR and spin echo formation is explained.
A next part of the course focuses on different advanced 1D and 2D NMR techniques (liquid NMR) used for structural analysis, whereby a focus is put on the applicability and analysis of the spectra. Using recent literature, it will be illustrated how an integrated use of different NMR techniques and molecular modelling can reveal essential information on the molecular structure. It will be shown how NMR can also reveal essential dynamic information (chemical exchange and molecular diffusion). The student will also learn why solid-state NMR requires a different approach than liquid NMR.
In a following part, EPR spectroscopy is introduced and the conceptual similarities and differences with NMR are highlighted. Some of the main EPR techniques are explained with an emphasis on their applicability and the information that they reveal about the electronic structure, the geometric structure and dynamics of the molecule.