The course module “Automatization and scale up” consists of two parts:
Part “Process technologie: scale up” (1 credit): This part is taught by Dr. M. Guillaume, ir. T. Spittaels and ir. B. De Witte. The student acquires a general insight in the manner the synthesis of API’s (Active Pharmaceutical Ingredients) are developed to allow a process applicable on ton scale.
The essential differences between a process on la scale and large scale will be explained: comparison with literature data, choice of solvent, reagents, catalysts, reaction parameters. Determination of ideal conditions for work up, obtaining desired compound in ad hoc form (solution or crystalline form), process control and end analysis, … Differences between operations on small/large scale and impact on the efficiency of the processes.
Part “Automatization” (2 credits): This part is taught by Dr. E. De Smedt. The aim is to deliver an insight in the different concepts, systems and apparatus used for industrial process automatization. The construction of real automatization loops will be illustrated by some specific cases. Besides the important measurement techniques also control and steering engineering will be extensively discussed. Modern processes are controlled by complex process computer systems. The construction of this, both concerning hardware and software, is an essential part of the course. The methods to visualize a process and their opportunities and problems will also be treated. Finally process safety will also be discussed.
Within the framework of this course module a company visit to Johnson&Johnson Geel is planned under the direction of Prof. B. Maes and Dr. M. Guillaume.