A correct use of antimicrobial drugs has important implications for therapeutic success, economy as well as for ecology. A good antibiotics policy is essential. This course can provide recent information of high quality that can be incorporated in the daily practices of the pharmacist. There will be an overview of the important resistances, their mechanisms and the relation between resistance of bacteria and the use of antibiotics. The new antibiotics, which were developed to control the multi resistant bacteria, will be discussed. Furthermore, the course will shed a light on pharmacokinetics and pharmacodynamics. Finally, an important part of this course concerns the review of guidelines for the use of antibiotics in different clinical situations.