Advanced Molecular Neurosciences

Course Code :2019FBDBIC
Study domain:Biomedical Sciences
Academic year:2018-2019
Semester:2nd semester
Contact hours:30
Credits:4
Study load (hours):112
Contract restrictions: Exam contract not possible
Language of instruction:English
Exam period:exam in the 2nd semester
Lecturer(s)Albena Jordanova

3. Course contents *

  1. Molecular and cellular architectonics of the nervous tissue. Cellular components. The role of neuron-glia interaction. Sub-cellular organization – organelles and their function in health and disease;
    -        cytoskeleton dynamics;
    -        mitochondrial function and dysfunction in the nervous system.
     
  2. Synthesis, turnover and trafficking of neuronal proteins and RNA. Neuronal defects related to protein and RNA metabolism;
    -        Axonal transport mechanics; fast vs. slow, retrograde vs. anterograde transport; axonal transport defects as a cause of neurodegeneration;
    -        Protein synthesis – cell body vs. extrasomatic protein synthesis;
    -        Protein misfolding, chaperone networks and the heat shock response in the nervous system;
    -        Polyglutamine disorders.
     
  3. Principles of excitation and transmission in the NS
    -        Neuronal channels and receptors; Inherited epilepsies;
    -        Neurotransmitters – types, metabolism, role in neuropsychiatry disorders and pharmacotherapy;
    -        Signal transmission at the neuromuscular junction and related disorders.
     
  4. Programmed cell death: genetics and role in neurodegenerative disorders.

    5.   Oxidative stress in neurodegeneration and stroke.

    6.   Approaches in molecular neuroscience research. Genetics as a tool in neurology. Cellular and animal models – advantages and disadvantages.