Deze cursusinformatie geeft aan hoe het onderwijs zal verlopen bij pandemieniveau code geel en groen.
Als er tijdens het academiejaar aangepast wordt naar code oranje of rood, zijn er wijzigingen mogelijk o.a. in de gebruikte werk - en evaluatievormen.

Advanced Molecular Neurosciences

Course Code :2019FBDBIC
Study domain:Biomedical Sciences
Academic year:2020-2021
Semester:2nd semester
Contact hours:30
Credits:4
Study load (hours):112
Contract restrictions: Exam contract not possible
Language of instruction:English
Exam period:exam in the 2nd semester
Lecturer(s)Albena Jordanova

3. Course contents *

  1. Molecular and cellular architectonics of the nervous tissue. Cellular components. The role of neuron-glia interaction. Sub-cellular organization – organelles and their function in health and disease;
    -        cytoskeleton dynamics;
    -        mitochondrial function and dysfunction in the nervous system.
     
  2. Synthesis, turnover and trafficking of neuronal proteins and RNA. Neuronal defects related to protein and RNA metabolism;
    -        Axonal transport mechanics; fast vs. slow, retrograde vs. anterograde transport; axonal transport defects as a cause of neurodegeneration;
    -        Protein synthesis – cell body vs. extrasomatic protein synthesis;
    -        Protein misfolding, chaperone networks and the heat shock response in the nervous system;
    -        Polyglutamine disorders.
     
  3. Principles of excitation and transmission in the NS
    -        Neuronal channels and receptors; Inherited epilepsies;
    -        Signal transmission at the neuromuscular junction and related disorders.
     
  4. Programmed cell death: genetics and role in neurodegenerative disorders.

    5.   Genetic factors and molecular pathways associated with addiction disorders.

    6.   Approaches in molecular neuroscience research. Genetics as a tool in neurology. Cellular and animal models – advantages and disadvantages.