Toxicological tracers and working mechanisms

Course Code :2024FBDBMW
Study domain:Pharmaceutical Sciences
Academic year:2019-2020
Semester:1st semester
Contact hours:39
Credits:6
Study load (hours):168
Contract restrictions: Exam contract not possible
Language of instruction:Dutch
Exam period:exam in the 1st semester
Lecturer(s)Lucia Vergauwen
Adrian Covaci
Birgit Mertens
Steven Van Cruchten

3. Course contents *

Effects of environmental chemical or physical agents on cells, organs and tissues. Emphasise is given on genetic toxicology, endocrine disruptors, reproduction toxicology etc.

Course:

Luc Verschaeve (14h)

a. Toxicology: Toxicokinetics and toxicodynamics,  general principles

b. Carcinogenesis via genetic and epigenetic effects, introduction to biomarkers

c. Genetic toxicology:

- testbattery for testing genetic effects: environmental monitoring, biomonitoring, product testing –Description of the main tests (bacterial-, mammalian- or human cells) and their applications in environmental and human toxicology

-Example of agents with different mechanisms of action

 -Mutagenese en antimutagenese

-Examples of tests in real situations

Adrian Covaci (6h)

-Main classes of environmental contaminants

- Structure and  properties

-Human exposure

-Toxicity

-Analytical methods and measurements

Hugo Neels (3h)

-Toxicity of the main 'drugs of abuse' and alcohol

Ingrid De Meester (3h)

-Liver toxicity and metabolic enzymes

Steven Husson (6h)

-REACH, legislation

-Effect analysis and alternative strategies

-Application of 'omics' technology (transcriptomics and proteomics) in environmental health research to elucidate working mechanisms of toxic agents

-Examples of applications and case studies; e.g., endocrine disruptors, effects of mixtures and natural variables

 

PRACTICAL WORK:

-Visit to WIV-ISP (Brussels)  & hands on training (genetic toxcicology): 6h

-Visit to Vito (Mol/Geel) & hands on training ): 6h

Visit laboratory of Toxicology (UA): 2h

Visit to laboratory Sphere (UA): 2h