Research topics

The application fields in which the Centre for Proteomics instrumentation is used, span a very wide range of research topics. Typically, every core research group has its own research interest.

In short, these research fields can be described as:

Clinical Proteomics (VITO-UAntwerp)

  • Immunopeptidomics
  • Peptide-centric proteomics for identification and PTM characterization
  • Quantitative proteomics by label-free or labelled analysis workflows
  • Peptidomics: characterization and quantification
  • Targetted measurements of proteins and peptides via SRM, PRM
  • Protein co-purification technology, e.g., ASBA membrane protein enrichement, etc.
  • Isolation of extra-cellular vesicles and exosomes
  • Analytical and technological proteomics expertise
  • Translational research – from bench to bedside
  • Data-mining and bio-informatics for proteomics and mass spectrometry
  • Development of software suites for customized analysis
  • Imaging mass spectrometry

Proteinchemistry, proteomics and epigenetic signalling – PPES (UAntwerp)

  • Differential (chemo)proteomics for cancer research
  • PTM analysis and biomarker identification.
  • MRM quantification of cancer biomarker proteins
  • OBOC hexapeptide identification
  • Differential proteomics in biofilm formation and evaluation of treatment
  • Native MS and ion mobility approaches for structural biology of heme-proteins
  • Study of membrane proteins using native MS
  • Effect of oxidative stress on heme-proteins

Systemic Physiological & Ecotoxicological Research -  SPHERE (UAntwerp)

  • In search for mechanistic insights (mode-of-action) of (environmental) toxicants
  • Identification of molecular classifiers and their relation to toxicity at higher levels of organization
  • Mechanistic insights of mixed stress scenarios (exposures to multiple compounds)
  • Effects of confounding factors (like temperature deviations)
  • Toxicity of environmentally persistend pharmaceutical pollutants
  • Differential peptidomics: in search for effects on endogenously occurring peptides
  • Differential proteomics

Biomolecular & Analytical Mass Spectrometry – BAMS (UAntwerp)

  • Development of novel separation, identification and fragmentation techniques for proteomics, peptidomics and metabolomics.
  • MS imaging of biomolecules (SIMS)
  • Native MS and ion mobility approaches for structural biology.
  • Chemical crosslinking, HDX and covalent labelling.
  • Biopharmaceuticals characterization. Ligand binding studies.
  • Molecular modelling and gas-phase characterization (spectroscopy).
  • (Isomer) separation and characterization of drug-like molecules using ion mobility MS. Native MS and ion mobility approaches for structural biology.

Translational neurobiology (VIB-UAntwerp)

  • Quantitative spatiotemporal proteomics of neurodegenerative diseases
  • iTRAQ/TMT and SILAC-based proteomic analysis
  • Proteomics-based molecular disease signature analysis
  • Receptor-based phosphoproteomic signal transduction profiling
  • Intelligent plasma proteome investigation
  • Bioinformatic software application development
  • Differential and quantitative interactomics
  • Multo-tissue based proteomic investigation of pathological aging

More info about the different research topics can be found on the webpages of the respective CORE research groups.