Identify epigenomic targets of medicinal natural compounds, steroid hormones and hypoxia mimetics in models of cancer-inflammation, cardiovascular disease and neuroplasticity Epigenetic modulator effects of different medicinal compounds will be characterized at the level of DNA methylation and activities of chromatin modifier enzymes (writer/eraser/reader) in relation to therapy sensitivity (chemo/hormone resistance), cardioprotection (atherosclerosis), or cognitive functions (behaviour, memory)
Characterize the epigenetic role of steroid responsive microRNAs in hormone therapy responses in cancer-inflammation (mirnomics, transcriptomics)
Characterize intracellular protein targets of phytochemicals with epigenome targeting properties on a proteome-wide scale (chemoproteomics, transcriptomics)
Applying systems biology approaches to integrate epigenomic, transcriptomic, microRNomic, (chemo)proteomic datasets to identify key signalling pathways and molecular targets of medicinal phytochemicals.
If you want to read more please click here or contact Wim Vanden Berghe (email@example.com).