Programme
- 08:30 – 09:15 | Registration
09:15 – 09:25 | Opening remarks by Prof Dr Anna Jansen
09:25 – 09:55 | Prof Dr Stéphanie Baulac (Paris Brain Institute, Paris, France)
Brain mosaicism in epilepsy and cortical malformations
09:55 | Jessica Rosenblum
Transcriptome analysis of cortical malformations: building disease signatures
10:10 | Zakaria Eddafir
Long-read genome sequencing resolves complex structural variants in exome-negative developmental and epileptic encephalopathy
10:25 | Kirsten Stam
Antagonistic effects of Fat4 and Dchs1 on RhoA activity, neuronal migration, and dendritogenesis
10:40 – 11:00 | Coffee break
11:00 | Noortje Zonnekein
Modeling KCNQ2 encephalopathy using iPSC-derived excitatory-inhibitory neuronal networks
11:15 | Dr Matthias De Wachter
4-aminopyridine in KCNA2-GOF-related DEE: the challenges of precision medicine in clinical practice
11:30 – 12:00 | Elly Lewerissa (Nael Nadif Kasri Lab, Radboudumc, Nijmegen, The Netherlands)
CHD2 links lysosomal function to the timing of human brain development
12:00 – 13:00 | Lunch - 13:00 | Prof Dr Sarah Weckhuysen (VIB Antwerp)
13:20 | Lara Colombo (FunGen Lab, UGent)
Systematic comparative analysis of 3D genome structure between neuronal and clinically accessible tissues highlights tissue-specific chromatin features at disease loci
13:40 | Rachel Schot (Erasmus MC)
14:00 – 14:30 | Prof Dr Verónica Martinez-Cerdeño (UC Davis, California, USA)
Interneuron deficiencies in autism
14:30 – 15:00 | Coffee break
15:00 – 15:30 | Dr Míriam Javier Torrent (GIGA NeuroGenesis (Laurent Nguyen lab), Université de Liège)
NEDD4-2 in Cortical Interneuron Migration and Brain Malformations
15:30 | Dr Renske Oegema (UMC Utrecht)
TEBiVANED: complex genotype-phenotype correlations in a rare histonopathy
15:50 – 16:20 | Prof Dr Hilde van Esch (KU Leuven)
In vivo xenotransplantation model to study neurodevelopmental disorders: MECP2-related disorders as an example
16:20 – 16:30 | Closing remarks by Prof Dr Marije Meuwissen
16:30 – 18:00 | Networking reception