The MS Vision High Mass Q-Tof (based on a Waters Q-TOF II) is optimized for studies of large, non-convalent protein complexes. It offers enhanced sensitivity for high mass species and allows tandem MS on precursor ions up to 30,000 m/z, based on the modifications originally published in F. Sobott, H. Hernández, M.G. McCammon, M.A. Tito, C.V. Robinson. Anal. Chem. 74 (2002), 1402.
Standard Q-Tof instruments are limited in their capacity to analyze high mass species. This is due to many design characteristics which have been developed for optimal performance in proteomics applications. Performance for high mass applications can be improved by careful modification of individual instrumental details. MS Vision have bundled a number of instrument modifications into a commercially modified Q-TOF II.