Experimental Neurobiology Unit

Publications

Real-world brain volumetry in multiple sclerosis : importance of methodological consistency and clinical relevance of gray matter atrophy

Source
Frontiers in neurology - ISSN 1664-2295-16 (2025) p. 1-12
Author(s)
    Joke Temmerman, Ann Vanremoortel, Maria Bjerke, Marie B. D'hooghe, Guy Nagels, Ayla Pauwels, Diana Sima, Dirk Smeets, Jeroen Van Schependom, Mandy Wittens, Sebastiaan Engelborghs, Miguel D'haeseleer

The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts

Source
Alzheimer's & dementia - ISSN 1552-5260-21:10 (2025) p. 1-12
Author(s)
    Veerle Van Gils, Willemijn J. Jansen, Wiesje M. Van Der Flier, Pablo Martinez-lage, Jakub Hort, Inez H.G.B. Ramakers, Olivier Rouaud, Markku Laakso, Sebastiaan Engelborghs, Julius Popp, Alberto Lleo, Anders Wallin, Magda Tsolaki, Charlotte E. Teunissen, Rik Vandenberghe, Yvonne Freund-levi, Lutz Frolich, Henrik Zetterberg, Johannes Streffer, Simon Lovestone, Justine Moonen, Argonde Van Harten, Katerina Veverova, Nienke Legdeur, Anouk Den Braber, Daniel Damian, Anette Hall, Janita Bralten, Giuseppe Fanelli, Barbara Franke, Geert Poelmans, Monica Bullo, Susana Jimenez-murcia, Fernando Fernandez-aranda, Jordi Salas-salvado, Soren Dalsgaard, Pieter Jelle Visser, Stephanie J.B. Vos

Norepinephrine-induced intracellular Ca²+ increase is coupled with astrocytic BK channel activation and capillary response

Source
American journal of physiology : cell physiology - ISSN 0363-6143-329:4 (2025) p. C1061-C1074
Author(s)
    Jelena Bogdanovic Pristov, Danijela Bataveljic, Dunja Bijelic, Katarina Milicevic, Jelena Korac Jacic, Ljiljana Nikolic

Assessing the link between cerebellar volume and cognitive function in Alzheimer's disease : a pilot study

Source
Scientific reports - ISSN 2045-2322-15:1 (2025) p. 1-12
Author(s)
    Deborah Van Rossem, Gert-Jan Allemeersch, Nuno Barros, Joke Temmerman, Marijke Desmet, Ilka Ringoot, Annemie Ribbens, Veronique Michiels, Johan De Mey, Chris Baeken, Sebastiaan Engelborghs, Sara De Witte

Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease

Source
Alzheimer's & dementia - ISSN 1552-5260-21:10 (2025) p. 1-13
Author(s)
    Eleonora M. Vromen, Senne B. Lageman, Johan Gobom, Rik van der Kant, Valerija Dobricic, Lars Bertram, Johannes Streffer, Simon Lovestone, Stephanie J.B. Vos, Mikel Tainta, Yvonne Freund-Levi, Lutz Frolich, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Frans Verhey, Rik Vandenberghe, Jolien Schaeverbeke, Kaj Blennow, Sven J. van der Lee, Philip Scheltens, Yolande A.L. Pijnenburg, Wiesje M. van der Flier, Charlotte E. Teunissen, Henrik Zetterberg, Pieter Jelle Visser, Betty Tijms

Systemic inflammation as a central player in the initiation and development of Alzheimer's disease

Source
Immunity & ageing - ISSN 1742-4933-22:1 (2025) p. 1-26
Author(s)

Safety and immunogenicity of two Tau-targeting active immunotherapies, ACI-35.030 and JACI-35.054, in participants with early Alzheimer's disease : a phase 1b/2a, multicentre, double-blind, randomised, placebo-controlled study

Source
EBioMedicine - ISSN 2352-3964-120 (2025) p. 1-16
Author(s)
    Olivier Sol, Julien Mermoud, Merja Hallikainen, Sudhir Ku, Juha Rinne, Paul Dautzenberg, Everard G.B. Vijverberg, Catherine Mummery, Anne Borjesson-Hanson, Michael Jonsson, Craig Ritchie, Catherine Pennington, Marija Vukicevic, Eva Gollwitzer, Emma Fiorini, David T. Hickman, Valerie Hliva, Julian Gray, Viktoriia Gerasymchuk, Jonathan Wagg, Nicolas Fournier, Benedicte Le, Iva Kezic, Lennert Steukers, Gallen Triana-Baltzer, Clara Theunis, Johannes Streffer, Marie Kosco-Vilbois, Andrea Pfeifer, Philip Scheltens

Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia

Source
Molecular neurodegeneration - ISSN 1750-1326-20:1 (2025) p. 1-17
Author(s)
    Yanaika S. Hok-A-Hin, Lisa Vermunt, Carel F.W. Peeters, Emma L. van der Ende, Sterre C.M. de Boer, Lieke H. Meeter, Julie de Houwer, Harro Seelaar, John C. van Swieten, William T. Hu, Alberto Lleo, Daniel Alcolea, Sebastiaan Engelborghs, Anne Sieben, Alice Chen-Plotkin, David J. Irwin, Wiesje M. van der Flier, Yolande A.L. Pijnenburg, Charlotte E. Teunissen, Marta del Campo

Comment by European Alzheimer's Disease Consortium (EADC) investigators on the negative recommendation of the CHMP on the marketing authorization of donanemab for early Alzheimer' s disease

Source
Journal of Prevention of Alzheimer's Disease - ISSN 2274-5807-12:8 (2025) p. 1-5
Author(s)
    Frank Jessen, Javier Arbizu, Merce Boada, Mircea Balasa, Karim Bennys, Marina Boban, Katharina Burger, Andrea Chincarini, Annachiara Cagnin, Peter Paul De Deyn, Emrah Duezel, Sebastiaan Engelborghs, Michael Ewers, Lieza G. Exalto, Wiesje M. van der Flier, Juan Fortea, Kristian Steen Frederiksen, Giovanni B. Frisoni, Lutz Froelich, Alejandro J. Garza-Martinez, Timo Grimmer, Bernard Hanseeuw, Jakub Hort, Adrian Ivanoiu, Patrick G. Kehoe, Sean P. Kennelly, Silke Kern, Stefan Kloeppel, Lenka Krajcovicova, Milica G. Kramberger, Bernadette McGuinness, Patrizia Mecocci, Timo Jan Oberstein, Pierre-Jean Ousset, Claire Paquet, Robert Perneczky, Fabrizio Piazza, Domenico Plantone, Innocenzo Rainero, Guillaume Sacco, Eric Salm, Isabel Santana, Nikolaos Scarmeas, Anja Schneider, Jonathan M. Schott, Eino Solje, Elka Stefanova, Elisabeth Stogmann, Melanie Strauss, Bengt Winblad

Disease progression biomarkers in multiple sclerosis : paving the way towards implementation in clinical practice

Source
Antwerp, University of Antwerp & Vrije Universiteit Brussel, 2025,iv, v, 184 p.
Author(s)

Modulating language and executive functions in bilingual aphasia with cerebellar tDCS : a case series

Source
Brain and language - ISSN 0093-934X-269 (2025) p. 1-17
Author(s)

Independent validation and outlier analysis of EuroPOND alzheimer's disease staging model using ADNI and real-world clinical data

Source
Alzheimer's research & therapy - ISSN 1758-9193-17:1 (2025) p. 1-15
Author(s)
    Mandy Wittens, Diana M. Sima, Arne Brys, Hanne Struyfs, Ellis Niemantsverdriet, Ellen De Roeck, Christine Bastin, Florence Benoit, Bruno Bergmans, Jean-Christophe Bier, Peter Paul De Deyn, Olivier Deryck, Bernard Hanseeuw, Adrian Ivanoiu, Gaetane Picard, Eric Salmon, Kurt Segers, Anne Sieben, Evert Thiery, Jos Tournoy, Anne-Marie van Binst, Jan Versijpt, Dirk Smeets, Maria Bjerke, Maura Bellio, Neil P. Oxtoby, Daniel C. Alexander, Annemie Ribbens, Sebastiaan Engelborghs

Navigating the introduction of anti-amyloid therapy in Europe : a position statement by individual members of the EADC

Source
Alzheimer's research & therapy - ISSN 1758-9193-17:1 (2025) p. 1-9
Author(s)
    Kristian S. Frederiksen, Merce Boada, Bruno Dubois, Sebastiaan Engelborghs, Giovanni B. Frisoni, Jean Georges, Jakub Hort, Linus Joensson, Milica G. Kramberger, Pierre-Jean Ousset, Nikolaos Scarmeas, Reinhold Schmidt, Jonathan M. Schott, Luiza Spiro, Gunhild Waldemar, Bengt Winblad, Frank Jessen, Lutz Frölich