Experimental Neurobiology Unit

Publications

Independent validation and outlier analysis of EuroPOND alzheimer's disease staging model using ADNI and real-world clinical data

Source
Alzheimer's research & therapy - ISSN 1758-9193-17:1 (2025) p. 1-15
Author(s)
    Mandy Wittens, Diana M. Sima, Arne Brys, Hanne Struyfs, Ellis Niemantsverdriet, Ellen De Roeck, Christine Bastin, Florence Benoit, Bruno Bergmans, Jean-Christophe Bier, Peter Paul De Deyn, Olivier Deryck, Bernard Hanseeuw, Adrian Ivanoiu, Gaetane Picard, Eric Salmon, Kurt Segers, Anne Sieben, Evert Thiery, Jos Tournoy, Anne-Marie van Binst, Jan Versijpt, Dirk Smeets, Maria Bjerke, Maura Bellio, Neil P. Oxtoby, Daniel C. Alexander, Annemie Ribbens, Sebastiaan Engelborghs

Navigating the introduction of anti-amyloid therapy in Europe : a position statement by individual members of the EADC

Source
Alzheimer's research & therapy - ISSN 1758-9193-17:1 (2025) p. 1-9
Author(s)
    Kristian S. Frederiksen, Merce Boada, Bruno Dubois, Sebastiaan Engelborghs, Giovanni B. Frisoni, Jean Georges, Jakub Hort, Linus Joensson, Milica G. Kramberger, Pierre-Jean Ousset, Nikolaos Scarmeas, Reinhold Schmidt, Jonathan M. Schott, Luiza Spiro, Gunhild Waldemar, Bengt Winblad, Frank Jessen, Lutz Frölich

Monoaminergic alterations at the subregional cervical and thoracic spinal cord level of patients within the FTD-ALS continuum and early-onset AD : low thoracic dopaminergic activity in ALS

Source
Journal of neurochemistry - ISSN 0022-3042-169:3 (2025) p. 1-18
Author(s)

Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health

Source
Molecular neurodegeneration - ISSN 1750-1326-20:1 (2025) p. 1-26
Author(s)

Synaptic protein CSF levels relate to memory scores in individuals without dementia

Source
Alzheimer's research & therapy - ISSN 1758-9193-17:1 (2025) p. 1-15
Author(s)
    Kirsten E.J. Wesenhagen, Diederick M. de Leeuw, Jori Tomassen, Johan Gobom, Isabelle Bos, Stephanie J.B. Vos, Pablo Martinez-Lage, Mikel Tainta, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Rik Vandenberghe, Yvonne Freund-Levi, Frans Verhey, Simon Lovestone, Johannes Streffer, Valerija Dobricic, Kaj Blennow, Philip Scheltens, August B. Smit, Lars Bertram, Charlotte E. Teunissen, Henrik Zetterberg, Betty M. Tijms, Pieter Jelle Visser

Copy number variation and haplotype analysis of 17q21.31 reveals increased risk associated with progressive supranuclear palsy and gene expression changes in neuronal cells

Source
Movement disorders: video, videotape supplements - ISSN 0885-3185- (2025) p.
Author(s)
    Hui Wang, Timothy S. Chang, Beth A. Dombroski, Po-Liang Cheng, Ya-Qin Si, Albert Tucci, Vishakha Patil, Leopoldo Valiente-Banuet, Chong Li, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C. Van Swieten, Elise Dopper, Bernardino F. Ghetti, Kathy L. Newell, Claire Troakes, Justo G. de Yebenes, Alberto Rabano-Gutierrez, Tina Meller, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Mueller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G. Beach, Geidy E. Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A. Ross, Douglas Galasko, Adam L. Boxer, Bruce L. Miller, Willian W. Seeley, Vivianna M. Van Deerlin, Edward B. Lee, Charles L. White, Wan-Ping Lee

Automated quantitative structural magnetic resonance imaging volumetrics towards clinical application in Alzheimer’s disease

Source
Antwerp, University of Antwerp, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Department of Biomedical Sciences, 2025,389 p.
Author(s)

Strategies for mitigating data heterogeneities in AI-based neuro-disease detection

Source
Neuron - ISSN 0896-6273-113:8 (2025) p. 1129-1132
Author(s)

Identifying pathways to the prevention of dementia : the Netherlands consortium of dementia cohorts

Source
BMC neurology - ISSN 1471-2377-25:1 (2025) p. 1-9
Author(s)
    Julie E. Oomens, Justine E.F. Moonen, Stephanie J.B. Vos, Magdalena Beran, Pedro Mateus, Peter Paul De Deyn, Wiesje M. van der Flier, Mirjam I. Geerlings, Martijn A. Huisman, M. Arfan Ikram, Miranda T. Schram, P. Eline Slagboom, W.M. Monique Verschuren, Marian Beekman, Inigo Bermejo, Mahlet Birhanu, Esther E. Bron, Andre Dekker, Ingeborg Frentz, Swier J.F. Garst, Eva Jaarsma, Almar A.L. Kok, Sofia Marcolini, Leon Mei, Eric P. Moll van Charante, Edo Richard, Casper G. Schalkwijk, Thomas T. van Sloten, Charlotte E. Teunissen, Emma L. Twait, Inge M.W. Verberk, Jet M.J. Vonk, Marjo P.H. van de Waarenburg, Frank J. Wolters, Willemijn J. Jansen, Pieter Jelle Visser

Depressive symptoms and amyloid pathology

Source
JAMA psychiatry - ISSN 2168-622X- (2025) p.
Author(s)
    Wietse A. Wiels, Julie E. Oomens, Sebastiaan Engelborghs, Chris Baeken, Christine A.F. von Arnim, Merce Boada, Mira Didic, Bruno Dubois, Tormod Fladby, Wiesje M. van der Flier, Giovanni B. Frisoni, Lutz Froehlich, Kiran Dip Gill, Timo Grimmer, Helmut Hildebrandt, Jakub Hort, Yoshiaki Itoh, Takeshi Iwatsubo, Aleksandra Klimkowicz-Mrowiec, Dong Young Lee, Alberto Lleo, Pablo Martinez-Lage, Alexandre de Mendonca, Philipp T. Meyer, Elisabeth N. Kapaki, Piero Parchi, Matteo Pardini, Lucilla Parnetti, Julius Popp, Lorena Rami, Eric M. Reiman, Juha O. Rinne, Karen M. Rodrigue, Pascual Sanchez-Juan, Isabel Santana, Marie Sarazin, Nikolaos Scarmeas, Ingmar Skoog, Peter J. Snyder, Reisa A. Sperling, Sylvia Villeneuve, Anders Wallin, Jens Wiltfang, Henrik Zetterberg, Rik Ossenkoppele, Frans R.J. Verhey, Stephanie J.B. Vos, Pieter Jelle Visser, Willemijn J. Jansen

Creating the Pick’s disease International Consortium: Association study of MAPT H2 haplotype with risk of Pick’s disease

Source
medRxiv-23:5 (2024) p. 487-499
Author(s)
    Rebecca R. Valentino, William J. Scotton, Shanu F. Roemer, Tammaryn Lashley, Michael G. Heckman, Maryam Shoai, Alejandro Martinez-Carrasco, Nicole Tamvaka, Ronald L. Walton, Matthew C. Baker, Hannah L. Macpherson, Raquel Real, Alexandra I. Soto-Beasley, Kin Mok, Tamas Revesz, Elizabeth A. Christopher, Michael DeTure, William W Seeley, Edward B. Lee, Matthew P. Frosch, Laura Molina-Porcel, Tamar Gefen, Javier Redding-Ochoa, Bernardino Ghetti, Andrew C. Robinson, Christopher Kobylecki, James B. Rowe, Thomas G. Beach, Andrew F. Teich, Julia L. Keith, Istvan Bodi, Glenda M. Halliday, Marla Gearing, Thomas Arzberger, Christopher M. Morris, Charles L. White, Naguib Mechawar, Susana Boluda, Ian R. MacKenzie, Catriona McLean, Matthew D. Cykowski, Shih-Hsiu J. Wang, Caroline Graff, Rashed M. Nagra, Rosa Rademakers, Anne Sieben, Patrick Cras, Bart De Vil, Peter Paul De Deyn, Pick's disease International Consortium

Assessment of dementia in minority ethnic groups in Europe : a 14-year follow-up survey

Source
International journal of geriatric psychiatry: a journal of the psychiatry of late life and allied sciences - ISSN 0885-6230-39:12 (2024) p. 1-11
Author(s)
    T. Rune Nielsen, Alexandre de Mendonca, Lutz Frölich, Sebastiaan Engelborghs, Dianne Gove, Daphne Lamirel, Clara Calia, Gunhild Waldemar