Identify epigenomic targets of medicinal natural compounds, steroid hormones and hypoxia mimetics in models of cancer-inflammation, cardiovascular disease and neuroplasticity Epigenetic modulator effects of different medicinal compounds will be characterized at the level of DNA methylation and activities of chromatin modifier enzymes (writer/eraser/reader) in relation to therapy sensitivity (chemo/hormone resistance), cardioprotection (atherosclerosis), or cognitive functions (behaviour, memory)
Characterize the epigenetic role of steroid responsive microRNAs in hormone therapy responses in cancer-inflammation (mirnomics, transcriptomics)
Characterize intracellular protein targets of phytochemicals with epigenome targeting properties on a proteome-wide scale (chemoproteomics, transcriptomics)
Applying systems biology approaches to integrate epigenomic, transcriptomic, microRNomic, (chemo)proteomic datasets to identify key signalling pathways and molecular targets of medicinal phytochemicals.
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