Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models

Source
bioRxiv - ISSN 2692-8205- (2024) p.
Author(s)
    Dimitra Sokolova, Shari Addington Ghansah, Francesca Puletti, Tatiana Georgiades, Sebastiaan De Schepper, Yongjing Zheng, Gerard Crowley, Ling Wu, Javier Rueda-Carrasco, Angeliki Koutsiouroumpa, Philip Muckett, Oliver J. Freeman, Baljit S. Khakh, Soyon Hong

Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models

Source
The EMBO journal - ISSN 1460-2075-42:19 (2024) p. 1-18
Author(s)
    Javier Rueda-Carrasco, Dimitra Sokolova, Sang-Eun Lee, Thomas Childs, Natália Jurčáková, Gerard Crowley, Sebastiaan De Schepper, Judy Z. Ge, Joanne I. Lachica, Christina E. Toomey, Oliver J. Freeman, John Hardy, Samuel J. Barnes, Tammaryn Lashley, Beth Stevens, Sunghoe Chang, Soyon Hong

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease

Source
Nature neuroscience - ISSN 1546-1726-26:3 (2023) p. 406-415
Author(s)
    Sebastiaan De Schepper, Judy Z. Ge, Gerard Crowley, Laís S.S. Ferreira, Dylan Garceau, Christina E. Toomey, Dimitra Sokolova, Javier Rueda-Carrasco, Sun-Hye Shin, Jung-Seok Kim, Thomas Childs, Tammaryn Lashley, Jemima J. Burden, Michael Sasner, Carlo Sala Frigerio, Steffen Jung, Soyon Hong