Research Kayhan Ilbeigi

Abstract

Trypanosoma theileri, a globally widespread parasite traditionally considered non-pathogenic in cattle, is drawing increasing attention due to its potential role in livestock health, particularly in immunocompromised or co-infected hosts. Despite its high prevalence, critical knowledge gaps remain regarding T. theileri's prevalence, genetic diversity, host interactions, and immune modulation. This project aims to address these gaps through a multi-pronged approach, starting with the first comprehensive mapping of T. theileri prevalence in Belgium, coupled with multigene phylogenetic analyses to classify strains and determine their lineage. To unravel infection dynamics, we will develop a novel murine model to study tissue-specific parasite tropism and immune interactions, focusing on the lungs as a known trypanosome niche. This model will enable detailed investigation into T. theileri's role in respiratory co-infections, including interactions with bovine respiratory syncytial virus (BRSV). Finally, we will examine the parasite's impact on immune modulation, particularly lung immune responses and vaccine-induced immunity. By addressing these gaps, this project will deliver the first epidemiological data on T. theileri in Belgium, establish an experimental model for studying its pathogenesis, and provide novel insights into immune modulation and co-infection dynamics. The outcomes will advance veterinary parasitology and improve livestock health management worldwide.

Researcher(s)

• Promoter: Caljon Guy
• Fellow: Ilbeigi Kayhan

Research team(s)

• Laboratory for Microbiology, Parasitology and Hygiene (LMPH)

Project type(s)

• Research Project