The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease

Source
Nature communications - ISSN 2041-1723-16:1 (2025) p. 1-15
Author(s)

APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia

Source
EMBO molecular medicine - ISSN 1757-4676-16:12 (2024) p. 3113-3141
Author(s)
    Pranav Preman, Daan Moechars, Emre Fertan, Leen Wolfs, Lutgarde Serneels, Disha Shah, Jochen Lamote, Suresh Poovathingal, An Snellinx, Renzo Mancuso, Sriram Balusu, David Klenerman, Amaia M. Arranz, Mark Fiers, Bart De Strooper

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems

Source
Cell reports - ISSN 2211-1247-43:11 (2024) p. 1-22
Author(s)
    Amy F. Lloyd, Anna Martinez-Muriana, Emma Davis, Michael J.D. Daniels, Pengfei Hou, Renzo Mancuso, Alejandro J. Brenes, Linda V. Sinclair, Ivana Geric, An Snellinx, Katleen Craessaerts, Tom Theys, Mark Fiers, Bart De Strooper, Andrew J.M. Howden

Immune activation in Alzheimer disease

Source
Annual review of immunology - ISSN 0732-0582-42 (2024) p. 585-613
Author(s)