Abstract
The global markets for pharmaceutical and agrochemical products commercialized as single enantiomers represent substantial industries. Enantioselective catalysis selectively provides one enantiomer, playing a critical role in minimizing waste and reducing resource costs, aligning with sustainable chemical processes. However, industrial photocatalysis faces challenges like limited light penetration, photodegradation, and the need for multiple catalysts, increasing cost and complexity. Red light photocatalysis addresses these issues with deeper penetration, making it suitable for industrial applications. This research aims to develop homochiral atropisomeric N-confused porphyrins (NCPs) as enantioselective red light photocatalysts. NCPs naturally absorb red light, and the installed chelating atropisomeric structure ensures enantioselectivity, while transition metal complexation eliminates the need for multiple catalysts. The project will focus on synthesizing NCPs and introducing functional groups, exploring scalable, sustainable methods. Homochiral atropisomeric NCPs will be synthesized via Suzuki and condensation reactions. The obtained compounds will be characterized for stability, chiral properties, and photophysical behavior. NCP photocatalysts will be tested in enantioselective red light reactions to achieve high enantiomeric excess and yield. The project will promote greener chemical manufacturing, advancing sustainable production and fostering industrial collaborations.
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