Research team
Expertise
Modelling and cost-effectiveness analyses of vaccination strategies against infectious diseases become my great interest and passion. I have more than 12 years of experience conducting health economics evaluations on several vaccines, including hepatitis B, human papillomavirus, rotavirus, pertussis, varicella and influenza. My previous professional experience includes: burden of disease studies, systematic literature reviews, cost-effectiveness and budget impact analyses, quality of life studies, dynamic transmission models, model compariosn, development of reimbursement dossiers, project management, and communication with various stakeholders. I am a member of RESCEU (REspiratory Syncytial virus Consortium in EUrope) and PROMISE (Preparing for RSV immunisation and surveillance in Europe). My primary research topic is the multi-country economic evaluations of interventions against RSV, influenza, and rotavirus.
Valuing new combination vaccines in national immunization schedules.
Abstract
Background: Combination vaccines (CVs) are vital to relieve crowded immunization schedules. Several more are in the pipeline, but they are likely expensive. Understanding their innovative nature and value for health care and society is crucial for relevant economic assessments. Aim: Instead of the traditional approach of summing the effects of individual components in a CV and estimating direct health care savings in vaccine delivery, a new approach will be developed to evaluate the broader value of combination vaccines. Methods: A systematic review will synthesize existing value estimates and methods for CVs. Surveybased discrete choice experiments will also assess acceptance, hesitancy, preference, and willingness-to-pay. A cost-effectiveness model will evaluate the value of an adult CV (i.e. influenza, RSV, Covid-19, hMPV), incorporating survey-derived preferences and values on coverage, convenience and time, costs (inc. delivery), and (the perception of) adverse events. Expected results: The review will highlight key extant methods and identify gaps in CV valuation. The survey will reveal preference patterns among target groups: caregivers for children, women of childbearing age, adult travelers, older adults, and healthcare professionals. The broader value of CVs will be quantified in monetary terms and in quality-adjusted life-years. These findings will inform a cost-effectiveness model, showcasing the broader value of a highly topical respiratory CV for adults.Researcher(s)
- Promoter: Beutels Philippe
- Fellow: Li Xiao
Research team(s)
Project type(s)
- Research Project