Abstract
Neuroglobin, a neuron specific heme protein, is believed to play a key role in the protection of the cells in stress conditions. The mechanism of this protection is however still a matter of debate.
In this project, both mice and neural stem cell based neuroglobin expression systems will be created, improved and validated forming the foundation for further in vitro and in vivo experimental setups. Subsequently, a profound differential transcriptomic and proteomic screening will reveal a first set of important players and signalling pathways linked to the specific neuroglobin expression pattern.
In addition, the role of neuroglobin after 17ß-estradiol induced
neurogenesis, and as such its role in neuroplasticity, will be evaluated.
Using in vitro and in vivo specific neuroglobin expression systems, we hope to
reveal the contribution of neuroglobin in vital brain processes. Unravelling the
fundamental molecular basis of these mechanisms will contribute to get insight in
brain's endogenous protective mechanisms.
Researcher(s)
Research team(s)
Project type(s)