The objective of this project is to investigate at a molecular level (metabolome) the developmental and neurotoxic effects of endocrine disruptors in whole zebrafish embryos with a focus on specific organs (e.g., brain, liver, heart, gills, kidney, eyes), study at high time resolution the development of the normal zebrafish metabolome until 5 dpf and link these to the development of organs and tissues using advanced mass spectrometry techniques including tissue imaging techniques (MSI). This will provide comprehensive information on the effects of EDCs on the metabolome and link these to developmental and neurotoxic adverse effects (e.g. behaviour).
- Host Institution: Vrije Universiteit Amsterdam, Netherlands
- Lead Supervisor: Pim Leonards, Amsterdam Institute for Life and Environment
- Subject area: Chemistry, neurotoxicity, mass spectrometry
