The main objective of this project is to determine the effects of EDC mixture exposure on thyroid hormone transport to the developing brain in novel human in vitro models and compare these effects to changes observed in cerebrospinal fluid thyroid hormone levels observed in humans and zebrafish. Selected real-life mixtures from the case studies will be tested for their effect on thyroid hormone transmembrane transporters (THTMTs) in dedicated THTMT-overexpressing cell lines as well as in human blood-cerebrospinal fluid barrier (BCSFB) organoid models and zebrafish embryos.
- Host Institution: Vrije Universiteit Amsterdam, Netherlands
- Lead Supervisor: Timo Hamers, Amsterdam Institute for Life and Environment
- Subject area: Toxicology, in vitro, hormones, mixtures
