This exciting research project is aimed at improving the predictability of testing frameworks for endocrine disruptors (EDs). This interdisciplinary project focuses on advancing our understanding of ED- mediated adverse effects by also addressing cross-axis activity and enhancing cross-species extrapolation to better identify and assess EDs. Anchored in the Adverse Outcome Pathway (AOP) framework, the project will contribute to advancing chemical safety assessment within a one-health context. DC2 will work on expanding AOP networks for endocrine-mediated reproductive toxicity, identifying key events and key event relationships with a focus on cross-species linking. The research will involve laboratory experiments using mammalian (e.g., rat) and non-mammalian models (e.g., zebrafish) to investigate mechanisms of endocrine disruption, including cross-axis interactions such as thyroid and retinoic acid signalling. Additionally, the project includes applying read-across approaches to fill critical data gaps, building on mechanistic insights and enhancing grouping strategies for EDs. This position provides an outstanding opportunity to conduct cutting-edge research with real-world applications in regulatory toxicology. The project includes close collaboration with leading institutions, offering a unique platform for interdisciplinary training, international research exchanges, and hands-on experience in experimental and computational methods. It is designed to train the next generation of risk assessors, with planned activities focusing heavily on learning and applying regulatory principles, from hazard identification to regulatory decision-making.
- Host Institution: Technical University of Denmark, Denmark
- Lead Supervisor: Terje Svingen, Molecular & Reproductive Toxicology
- Subject area: Risk assessment, AOP, reproduction, mammalian, human health
