The aim of this doctoral project is to explore a mechanism-based approach for identifying and assessing chemicals that may act as endocrine disruptors in humans. The project will be anchored in Adverse Outcome Pathway (AOP) methodology, which will be used as a framework to organize and integrate different types of data (in silico, in vitro, in vivo and human) and to establish links between early mechanistic events and apical health effects. The project will specifically explore the use of mechanistic data from the Zebrafish model, such as transcriptomics data, in the assessment of endocrine disruptors for human health, including considerations of cross-species extrapolations. As such, the project includes elements of experimental and computational work, as well as literature-based analyses. Application in the regulatory context is an important aspect.
- Host Institution: Institute of Environmental Medicine, Karolinska Institutet, Sweden
- Lead Supervisor: Anna Beronius, Unit of Biochemical Toxicology
- Subject area: Endocrine disruptor assessment for human health