The main objective of this research project is to gain a better understanding of interactions/crosstalk between endocrine axes in complex environmentally realistic mixtures using AOP network-based approaches. A known historical PFAS polluted site will be used as a case study. Human-relevant adverse health effects of PFAS exposure will be selected based on human biomonitoring studies and corresponding endpoints will be investigated in zebrafish embryos exposed to singles and mixtures of PFAS to study the contribution of mixture components.
- Host Institution: University of Antwerp, Belgium
- Lead Supervisor: Lucia Vergauwen, Zebrafishlab
- Subject area: Interactions/crosstalk, Human-relevant health effects, PFAS mixtures, AOP network, Zebrafish
