The key objectives of this project are to develop comprehensive analytical strategies for the characterization of the chemical exposome and metabolome of zebrafish in environmentally and human relevant complex scenarios and to apply these strategies to two case studies involving exposure to complex mixtures. Unified analytical workflows and strategies based on suspect and non-target screening and high resolution mass spectrometry will be developed for the simultaneous characterisation of the chemical exposome and metabolome of zebrafish embryos. Alterations in the metabolome will be linked to the chemical exposome in zebrafish exposed to mixtures relevant for environmental and human exposure.
- Host Institution: University of Antwerp, Belgium
- Lead Supervisor: Adrian Covaci, Toxicological Centre
- Subject area: Exposomics, Metabolomics, Chemical Exposure, Analytical Chemistry
