Studying human metabolism using in silico and in vitro techniques
What?
- Prediction and elucidation of Phase I & II metabolites & metabolic pathways
- Characterization of alterations in cellular metabolites
How?
- Elucidation of metabolism of chemicals using human liver microsomes (HLM)
- Comparison of in vitro results with in vivo samples
- Exposure of human cells to external stressors
- Bioinformatic and statistical tools
- Characterization of affected biochemical pathways