Research team
Expertise
Bioassay-guided isolation of active principles of medicinal plants Structure elucidation of natural products Drug analysis
Development of new antiparasitic lead compounds against malaria, trypanosomiasis en leishmaniasis : a multidisciplinary approach.
Abstract
Parasitic infections such as malaria, trypanosomiasis and leishmaniasis still make a lot of victims every year, especially in developing countries. The aim of this project is to investigate new lead compounds for drugs against these diseases using a multidisciplinary approach: characterisation of new leads from medicinal plants; further investigations of indoloquinoline derivatives, an existing lead; and design of inhibitors of trypanothionsynthetase and prolyloligopeptidase.Researcher(s)
- Promoter: Pieters Luc
- Co-promoter: Augustyns Koen
- Co-promoter: Haemers Achiel
- Co-promoter: Lemiere Guy
- Co-promoter: Vlietinck Arnold
Research team(s)
Project type(s)
- Research Project
Structure-activity relationship investigation in correlation with bioavailability of proanthocyanidins as nutritional antioxidants.
Abstract
Researcher(s)
- Promoter: Vlietinck Arnold
- Co-promoter: De Bruyne Tess
- Co-promoter: Vanden Berghe Dirk
Research team(s)
Project type(s)
- Research Project
Investigation of antioxidant and antiviral natural products from medicinal plants for developing a complementary therapeutical strategy against HSV- and HIV-infections.
Abstract
In this research antiviral and antioxidant compounds will be isolated from medicinal plants in order to develop a complementary therapeutical strategy against HSV- and HIV-infections.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: Cos Paul
Research team(s)
Project type(s)
- Research Project
Characterisation of the antimalarial constituents of 4 medicinal plants from Congo.
Abstract
This project deals with the characterisation of the antimalarial (antiplasmodial) constituents of 4 plants used in traditional medicine in Congo, the activity of which has been confirmed in preliminary in vivo experiments in mice, i.e. Phyllanthus niruri, Cassia occidentalis, Euphorbia hirta and Morinda morindoides. The aim of the project is to find new leads for antimalarial drugs, and to provide a scientific basis for the traditional use of local preparations, including the possibility of standardisation.Researcher(s)
- Promoter: Vlietinck Arnold
Research team(s)
Project type(s)
- Research Project
Structure elucidation of biologically active natural products as prototypes for new drugs.
Abstract
Biologically active natural products from higher plants are isolated and identified, to serve as prototypes for potential new drugs.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Bruyne Tess
Research team(s)
Project type(s)
- Research Project
Abstract
Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: Hermans Nina
Research team(s)
Project type(s)
- Research Project
Abstract
Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: Cimanga Kanyanga
Research team(s)
Project type(s)
- Research Project
Structure-activity relationship of triterpenes as selective endothelin receptor antagonists.
Abstract
The goal is to investigate a large numher of tetracyclic and pentacyclic triterpene aglycones for their potential antihypertensive action. In vitro radio ligand binding to receptors with known antihypertensive action such as ETA-receptors for endo-thelin-1 and ATl-receptors for angiotensin II will be used to characterize the active triterpenes. More specifically a structure-activity relationship study will be carried out on myriceric acid A. For that reason a practica! partial synthesis of 27-0-acyl-myriceron derivatives will be adapted.Researcher(s)
- Promoter: Vlietinck Arnold
Research team(s)
Project type(s)
- Research Project
Abstract
Researcher(s)
- Promoter: Vlietinck Arnold
- Co-promoter: Totte Jozef
Research team(s)
Project type(s)
- Research Project
Mass spectrometric structure characterisation of biomolecules and functional dyes: study of ionisation and fragmentation mechanisms, development of methods and analytical applications.
Abstract
The proposed research programme deals with mass spectrometric studies on the structural characterisation of biomolecules which will remain of fundamental biological interest and of functional dyes which are important for their material properties. The molecules which will be studied include lipide, plant glycoconjugates, peptides, proteins and aromatic oligomers and polymers. The objectives are to examine in detail and systematically the unimolecular chemistry of some of these compounds in the gas phase.Researcher(s)
- Promoter: Claeys-Maenhaut Magda
- Co-promoter: Geise Herman
- Co-promoter: Haemers Achiel
- Co-promoter: Pieters Luc
- Co-promoter: Vlietinck Arnold
Research team(s)
Project type(s)
- Research Project
Isolation, structure elucidation and standardization of the active components from extracts prepared from the fruits of Sabal serrulata and the herb of Echinacea purpurea.
Abstract
The aim of the project is to identify the active components of Sabal serrulata fruits, which is used often in combination with Echinacea purpurea for the treatment of benign prostatic hyperplasia (BHP) and to determine their mechanics of action.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Swaef Sabine
Research team(s)
Project type(s)
- Research Project
Development and optimalisation of an in vivo antioxidative testsystem.
Abstract
Development and optimalisation of an in vivo antioxidative testsystem.(lipid peroxidation) for the antioxidative evaluation of pure compounds and for the bioguided isolation of antioxidative compounds from plant material.Researcher(s)
- Promoter: Vlietinck Arnold
- Co-promoter: Vanden Berghe Dirk
Research team(s)
Project type(s)
- Research Project
Structure elucidation of biologically active natural products as prototypes for new drugs.
Abstract
Biologically active natural products from higher plants are isolated and identified, to serve as prototypes for potential new drugs.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Bruyne Tess
Research team(s)
Project type(s)
- Research Project
Structure elucidation of natural prototypes and synthetic analogues as potential new drugs by nuclear magnetic resonance (NMR) spectroscopy.
Abstract
Biologically active natural compounds from higher plants are used as prototype for the synthesis of analogues, to improve the activity, to study structure-activity relationship, in order to obtain potential new drugs. Structure of isolated and synthetic compounds will be elucidated using NMR spectroscopy.Researcher(s)
- Promoter: Pieters Luc
- Co-promoter: Haemers Achiel
- Co-promoter: Vlietinck Arnold
Research team(s)
Project type(s)
- Research Project
Isolation, structure elucidation and standardization of the active components from extracts prepared from the fruits of Sabal serrulata and the herb of Echinacea purpurea.
Abstract
The aim of the project is to identify the active components of Sabal serrulata fruits, which is used often in combination with Echinacea purpurea for the treatment of benign prostatic hyperplasia (BHP) and to determine their mechanics of action.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Swaef Sabine
Research team(s)
Project type(s)
- Research Project
Search for natural products with immunostimulating and/or anti-HIV activity.
Abstract
In view of the need for new drugs against AIDS, a viral disease suppressing the immune system, the aim of this project is to identify new natural products with potential immunostimulating and/or anti-HIV activity.Researcher(s)
- Promoter: Vlietinck Arnold
Research team(s)
Project type(s)
- Research Project
Determining European standards for the safe and effective use of phytomedicines.
Abstract
The objective is to publish agreed standards as Sumaries of Product Characteristics or monograph proposals for 200 phytomedicines in the member states of the European Community.Researcher(s)
- Promoter: Vlietinck Arnold
Research team(s)
Project type(s)
- Research Project
Structure activity relationship studies (SAR) and determination of the mechanism of action of antivirally active plant compound.
Abstract
New antiicornavirus flavonoids and antiherpes procyanidines will be synthetised and their antiviral activity will be determined. The investigation of the mechanism of action of these compounds will be continued.Researcher(s)
- Promoter: Vlietinck Arnold
- Co-promoter: Vanden Berghe Dirk
Research team(s)
Project type(s)
- Research Project
Search for plant components with immunostimulating and/or anti-HIV properties
Abstract
The active components of plant extracts with immunostimulating and/or anti-HIV properties will be isolated and identified using chromatographic and spectroscopic techniques. The biochemical mechanism of action will be investigated and determined.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: Lasure Aleidis M T A
Research team(s)
Project type(s)
- Research Project
Isolation and structure elucidation of biologically active natural compounds as prototypes of potential new drugs.
Abstract
This research project deals with the biologically guided isolation of natural compounds with chemotherapeutic, antimutagenic, antitumoral, immunomodulating and enzym-inhibiting properties, their structure elucidation by means of spectroscopic techniques and their development as prototypes of potential new drugs.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: Pieters Luc
Research team(s)
Project type(s)
- Research Project
Comparison of high-performance liquid chromatography, thin-layers densitometry, supercritical fluid chromatography and capillary electrophores in plant drug analysis.
Abstract
The aim of the project is to compare the possibilities of some recently developed analytical technique to separate, identify and assay plant phenolics and flavanoids in complex matrices such as galenical preparations.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Swaef Sabine
Research team(s)
Project type(s)
- Research Project
In vivo antioxidant activity of flavonoïds.
Abstract
The aim of this research project is to investigate the antioxidatieve effect of flavonoids in laboratory animals, by adding these compounds to the diet and determing their influence on the blood plasma malondialdehyde level.Researcher(s)
- Promoter: Vlietinck Arnold
Research team(s)
Project type(s)
- Research Project
Development of plant drugs.
Abstract
The aim of the project is to formulate plant drugs and to standardize their active constituents by modern analytical techniques.Researcher(s)
- Promoter: Vlietinck Arnold
- Co-promoter: Vanden Berghe Dirk
Research team(s)
Project type(s)
- Research Project
Isolation and structure elucidation of biologically active natural compounds as propotypes of potential new drugs.
Abstract
This project involves the biologically guided isolation of the active components of plants used in traditional medicine. When a pure, active compound has been obtained, its structure is elucidated by a combined use of spectroscopic techniques. The most interesting products may be used as prototypes for synthesis or semisynthesis of derivates, to improve the activity in order to obtain potential new drugs.Researcher(s)
- Promoter: Vlietinck Arnold
Research team(s)
Project type(s)
- Research Project
Synthesis and antiviral properties of aza-analogues of 3-mehtoxyflavones
Abstract
Improvement of the antiviral spectrum and activity of 3-methoxylflavones by introducing nitrogen in the A-ring of the flavonoid skeleton.Researcher(s)
- Promoter: Vlietinck Arnold
Research team(s)
Project type(s)
- Research Project
Comparison of high-performance liquid chromatography, thin-layers densitometry, supercritical fluid chromatography and capillary electrophores in plant drug analysis.
Abstract
The aim of the project is to compare the possibilities of some recently developed analytical technique to separate, identify and assay plant phenolics and flavanoids in complex matrices such as galenical preparations.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Swaef Sabine
Research team(s)
Project type(s)
- Research Project
Study of antimutagenic activity of flavonoids.
Abstract
Flavanoids are natural products occuring in plants and foodstuffs. They have mutagenic and antimutagenic properties, depending on their structure. The aim of this work is to investigate the structure-activity relationship and to characterise the most active antimutagenic flavonoids.Researcher(s)
- Promoter: Vlietinck Arnold
Research team(s)
Project type(s)
- Research Project
Search for new antivirally active natural compounds and optimalisation of their activity by structure-activity relationship studies.
Abstract
Antivirally active compounds isolated from medicinal plants will be used as lead products for the synthesis of analogues in order to optimize their antiviral and pharmacokinetic properties.Researcher(s)
- Promoter: Vlietinck Arnold
- Co-promoter: Haemers Achiel
- Co-promoter: Vanden Berghe Dirk
Research team(s)
Project type(s)
- Research Project
Search for plant components with immunostimulating and/or anti-HIV properties
Abstract
The active components of plant extracts with immunostimulating and/or anti-HIV properties will be isolated and identified using chromatographic and spectroscopic techniques. The biochemical mechanism of action will be investigated and determined.Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: Lasure Aleidis M T A
Research team(s)
Project type(s)
- Research Project
Chromatographic and structural investigations of ì chemotherapeutically active plant phenolicsì
Abstract
The structure of chemotherapeutically active plant condensed tannins viz. dimeric and trimeric procyanidines of the A, B and C-series will be determined by means of two dimensional nuclear magnetic resonance (2-D-NMR) spectrometryResearcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Bruyne Tess
Research team(s)
Project type(s)
- Research Project
Abstract
Researcher(s)
- Promoter: Vlietinck Arnold
- Fellow: Pieters Luc
Research team(s)
Project type(s)
- Research Project
Chromatographic and structural investigations of ì chemotherapeutically active plant phenolicsì
Abstract
The structure of chemotherapeutically active plant condensed tannins viz. dimeric and trimeric procyanidines of the A, B and C-series will be determined by means of two dimensional nuclear magnetic resonance (2-D-NMR) spectrometryResearcher(s)
- Promoter: Vlietinck Arnold
- Fellow: De Bruyne Tess
Research team(s)
Project type(s)
- Research Project