Clinical and (patho)genetic study of bicuspid aortic valve and associated aortic aneurysm. 01/01/2012 - 31/12/2015

Abstract

The general aim of this project is to gain insight into the clinical course of BAV-associated TAA, into the pathogenic mechanisms leading to aneurysm formation and to unravel the underlying genetic basis. In this project we will correlate a specific subclassification of bicuspid aortic valves (Sievers classification) with cardiovascular characteristics including co-morbidity, arterial stiffness and eccentric flow patterns. In addition, we will investigate the contribution of different developmental pathways and identify the genetic basis using state-of-the-art techniques including microRNA profiling, Copy Number Variant analysis and exome sequencing.

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Non invasive assessment of diastolic heart function: Doppler echocardiography and cardiovascular magnetic resonance. 01/10/2003 - 30/09/2005

Abstract

The thesis studies the capability of cardiovascular magnetic resonance to assess global and regional diastolic function using velocity encoding of both myocardial tissue and intracavitary flow. Filling parameters at rest and the impact of stress conditions (loading manipulations and b-adrenergic stimulation) will be analyzed and compared with Doppler.

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Research team(s)