Guido de Baere took his doctoral degree at KULeuven (Catholic University of Leuven, 1976) with a dissertation on the critical edition of Ruusbroec's Vanden seven sloten (The Seven Enclosures). Till 2006 he was editor-in-chief of the edition of the complete works of the same author (Opera Omnia). This voluminous edition was transformed into a compact one in cooperation with dr. Thom Mertens. It was published in 2014 under the title The Complete Ruusbroec. Since then, a critical edition of the mystical treatise Die evangelische peerle (The evangelical pearl, 1537) is being prepared.
From 1977 to 1988 he was a professor at the KUNijmegen, now Radboud University Nijmegen. From 1989 on he became a member of the Ruusbroecgenootschap.