In-stent restenosis remains a limitation of the percutaneous treatment modalities of coronary atherosclerosis. This project aims to develop 'single-component' and 'multi-component' directly coated drug eluting stents. Selective modulation of oxidative stress, smooth muscle cell migration and proliferation and endothelial cell regeneration are investigated, by single molecules, or combinations of locally delivered molecules. The used methodology consists of
stenttechnology, farmacokinetic evaluations, in-vitro and in-vivo biological research.