Investigation of the clinical relevance of high frequency stimulation patterns in the evaluation of the 3-dimensional vestibulo-ocular reflex in specific vestibular lesions.
AbstractHead movements are measured by means of the peripheral vestibular system. The vestibular information is centrally processed to induce compensatory eye movements in order to ensure gaze stabilization. This reflex is called the vestibulo-ocular reflex (VOR). The VOR works optimally for natural head movements, which are in the case of man, fast movements (1-4 Hz). In clinical settings, the VOR in the dizzy patient is typically investigated at low stimulation frequencies (0.05 HZ). The main goal of the project is to evaluate the function of the VOR at high stimulation frequencies, being more physiological. The VOR will be analyzed in three dimensions (horizontal, vertical and torsional) in patients with specific vestibular lesions, such as acoustic neuroma and in patients with autosomal dominant hearing impairment.
- Research Project
A placebo controlled multicentre study with budesonide 400 ug (RhinocortR Turbo-halerR) in the treatment of nasal polyps.
AbstractTo compare the clinical efficacy of budesonide (RhinocortR TurbohalerR) 400 /lg once daily with placebo in patients suffering from nasal polyps. Primary efficacy variable: Assessment of charges in size/position of polyps. Secondary efficacy variables: Assessment of changes in the estimation of the mass of the nasal polyps by endos-copy, using an imaging technic (video registration), individual and combined weekly symptom scores (nasal obstruction, rhinorrhea, sense of smeu and feeling of pressure in the head) and the patient's overall evaluation of treatment efficacy. Secondary objective: to compare the tolerability of budesonide with placebo. Primary safety variable: Registration of adverse events.
- Promoter: Claes Jozef
- Research Project