Research

Research group

Peripheral Neuropathies Group

Expertise

  • The Peripheral Neuropathy Group has expertise in mapping and identifying genes, and in studying the effect of mutations on the normal functioning of genes via neuronal and non-neuronal cell lines. This information is compared to clinical, neurophysiological and neuropathological data which are essential for genotype/phenotype correlations. The construction of transgenic models is complementary to the clinical and cellular research, and enables to unravel the pathomechanisms for sensory and/or motor neuropathies. We have further expertise in identifying genes through differential suppressive subtraction hybridisation in primary motor and sensory neurons, construction of cDNA libraries, identification of genomic and protein structures, and gene expression in neuronal and non-neuronal cells, including Schwann cells. We make use of transient and stable transformations, but also of the Crispr/Cas9 genome editing technology. In recent years we gained knowledge with microscopy technologies and the phenotyping of mouse and Drosophila models for peripheral neuropathies.

Projects

You can find here all of the projects that are recorded in the research database of UAntwerp under the name of the academic staff member that acts as a promoter, copromoter or grant holder (a.o. FWO). It concerns only those research projects and mandates that were acquired after an external or internal competition.